Cylindrocyclophanes with Proteasome Inhibitory Activity from the CyanobacteriumNostocsp.
نویسندگان
چکیده
منابع مشابه
Endoproteolytic activity of the proteasome.
The proteasome plays a central role in the degradation of regulatory and misfolded proteins. Current models suggest that substrates access the internal catalytic sites by processively threading their termini through the gated substrate channel. Here, we found that latent (closed) and activated (open) proteasomes degraded two natively disordered substrates at internal peptide bonds even when the...
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ژورنال
عنوان ژورنال: Journal of Natural Products
سال: 2010
ISSN: 0163-3864,1520-6025
DOI: 10.1021/np100352e